GENOTYPE COMPATIBILITY... EXAMPLE: AA + AA CAN MARRY ETC........


Genotype can be simply defined as the genetic constitution of an individual organism.


Genotype is totally different from your phenotype which is a description of your actual physical characteristics. It is incumbent  to know your genotype before you say “yes, I do” to that handsome guy or to that beautiful lady whom you wish to spend the rest of your life with.



GENOTYPE COMPATIBILITY


Types of Genotype

The genotypes in humans are AA, AS, AC, SS. They refer to the hemoglobin gene constituents on the red blood cells. AC is rare whereas AS and AC are abnormal.

Genotype Compatibility Chart

Study this table below carefully:

AA + AA = AA, AA, AA, AA (Excellent)

AA + AS = AA, AS, AA, AS, (Good)

AA + SS = AS, AS, AS, AS, (Fair)

AA + AC = AA, AA, AA, AC. (Good)

AS + AS = AA, AS, AS, SS, (Very Bad)

AS + SS = AS, SS, SS, SS, (Very Bad)

AS + AC = AA,  AC, AS,SS. (Bad; Advice needed)

SS + SS = SS, SS, SS, SS, (Very Bad)

AC + SS = AS, AS, SS, SS, (Very Bad)

AC + AC = AA, AC, AC, SS. ( Bad; Advice needed).


The problem to avoid with genotype compatibility for intending couples is the sickle cell disease (a recessive disorder)--a very serious medical condition with high prevalence rates in Africa south of the Sahara.



Compatible genotypes for marriage are:

AA marries an AA. That’s the best compatible. That way you save your future children the worry about genotype compatibility.


AA marries an AS. You’ll end up with kids with AA and AS which is good. But sometimes if you’re not lucky all the kids will be AS which limits their choice of partner.


AS and AS should not marry, there is every chance of having a child with SS.

AS and SS shouldn’t think of marrying.


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And definitely, SS and SS must not marry since there’s absolutely no chance of escaping having a child with the sickle cell disease.



Solution

The only thing that can change the genotype is the bone marrow transplant (BMT). It has been proven to be the only promising permanent cure to SS, SC, and CC; however, it is new, very expensive and cannot be done in any part of Africa. It also carries some risks.

Health tips are supplied by the AUN Health Center.